Vitamin D supplementation increases significantly insulin sensitivity in IGT patients ( 10). Lower circulating level of calcidiol was associated with the increased risk of coronary artery disease in diabetic patients ( 9). Therefore, the correction of vitamin D deficiency may result in improved glucose control and has beneficial effects on complications of diabetes type 2 ( 8). Vitamin D may also regulate glucose homeostasis by stimulating insulin release from pancreatic B-cells ( 6, 7). Vitamin D may facilitate insulin function by regulating its receptor expression, so it may be increases insulin sensitivity ( 5). There are several studies showing that vitamin D deficiency may resulted in developing diabetes type 2 ( 2– 4). Diabetes type 2 is a worldwide disease and it is estimated that at the end of 2030 more than 550 million people suffer from this disease ( 1).
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